I ran a guy with a new Toyota Tundra with my F-150. I've got the 5.4L and it's got the 3.73 rear end. My truck is a regular cab 2wd, the truck i ran was a 4wd 4dr extended cab. I figured my weight difference from not having the extended cab and the 4wd would equal things up. Wrongo!!!! As much as I dislike Toyota, those Tundra's are quick.
It was a 20-75 run and by that point he had 3 truck lengths on me and was pulling pretty good. He stepped down so I mashed it. He had only gone most of the way into it, and when I mashed it he planted his foot, so it wasn't a clean start. No matter how you look at it though the Ford didn't have the grunt to get the Toyota.
As a comparison I played with a guy I work with's Dodge Hemi 2wd extended cab and we are just about equal. It's a seesaw race between those two. Remeber my truck is a bunch lighter with no extended cab.
I'd say that Toyota is definately the fastest truck out there till you get into specialty stuff. Still wouldn't buy one though with all the problems Toyota is having right now.